Cancer Management and Research (Jan 2022)
The Characteristics of Tumor Microenvironment in Triple Negative Breast Cancer
Abstract
Yiqi Fan, Shuai He Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, People’s Republic of ChinaCorrespondence: Shuai HeDepartment of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, People’s Republic of ChinaEmail [email protected]: Triple-negative breast cancer (TNBC) is a special subtype of breast cancer, accounting for 10– 20% of breast cancers with high intrinsic heterogeneity. Its unique immune microenvironment, including high expression of vascular endothelial growth factors, tumor infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and other molecules that promote the growth and migration of tumor cells, has been shown to play a dual role in the occurrence, growth, and metastasis of TNBC. Understanding the TNBC microenvironment is of great significance for the prognosis and treatment of TNBC. In this article, we describe the composition and function of immune cells in the TNBC microenvironment and summarize the major cytokine growth factors and chemokines in the TNBC microenvironment. Finally, we discuss the progress of TNBC, cytokine-induced killer cell therapy, and immune checkpoint therapy.Keywords: triple negative breast cancer, microenvironment, immune cells, immunotherapy
