The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4

Zitong Zhao; Zitong Zhao; Zitong Zhao; Jian He; Yibing Chen; Yibing Chen; Yibing Chen; Yuchang Wang; Yuchang Wang; Yuchang Wang; Chuansen Wang; Chuansen Wang; Chuansen Wang; Changwu Tan; Changwu Tan; Changwu Tan; Junbo Liao; Junbo Liao; Junbo Liao; Gelei Xiao; Gelei Xiao; Gelei Xiao

doi:10.3389/fnmol.2022.952036

Frontiers in Molecular Neuroscience (Sep 2022)

The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4

Zitong Zhao,
Zitong Zhao,
Zitong Zhao,
Jian He,
Yibing Chen,
Yibing Chen,
Yibing Chen,
Yuchang Wang,
Yuchang Wang,
Yuchang Wang,
Chuansen Wang,
Chuansen Wang,
Chuansen Wang,
Changwu Tan,
Changwu Tan,
Changwu Tan,
Junbo Liao,
Junbo Liao,
Junbo Liao,
Gelei Xiao,
Gelei Xiao,
Gelei Xiao

Affiliations

Zitong Zhao: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Zitong Zhao: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Zitong Zhao: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Jian He: Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China
Yibing Chen: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Yibing Chen: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Yibing Chen: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Yuchang Wang: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Yuchang Wang: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Yuchang Wang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Chuansen Wang: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Chuansen Wang: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Chuansen Wang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Changwu Tan: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Changwu Tan: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Changwu Tan: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Junbo Liao: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Junbo Liao: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Junbo Liao: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Gelei Xiao: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Gelei Xiao: Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, China
Gelei Xiao: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fnmol.2022.952036
Journal volume & issue: Vol. 15

Abstract

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Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder without a recognized cause. Aquaporins (AQPs) are transmembrane channels that carry water through cell membranes and are critical for cerebrospinal fluid circulation and cerebral water balance. The function of AQPs in developing and maintaining hydrocephalus should be studied in greater detail as a possible diagnostic and therapeutic tool. Recent research indicates that patients with iNPH exhibited high levels of aquaporin 1 and low levels of aquaporin 4 expression, suggesting that these AQPs are essential in iNPH pathogenesis. To determine the source of iNPH and diagnose and treat it, it is necessary to examine and appreciate their function in the genesis and maintenance of hydrocephalus. The expression, function, and regulation of AQPs in iNPH are reviewed in this article, in order to provide fresh targets and suggestions for future research.

Published in Frontiers in Molecular Neuroscience

ISSN: 1662-5099 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/molecular-neuroscience

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