International Journal of Nanomedicine (Mar 2020)
Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment
Abstract
Ji Wang,1,* Xia Wu,2,* Peng Shen,3 Jun Wang,4 Yidan Shen,1 Yan Shen,5 Thomas J Webster,6 Junjie Deng3 1Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Clinical Pharmacology, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 3Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, People’s Republic of China; 4Department of General Surgery, The Fifth People’s Hospital of Wujiang, Suzhou, People’s Republic of China; 5Department of Pharmaceutics, China Pharmaceutical University, Nanjing, People’s Republic of China; 6Department of Chemical Engineering, Northeastern University, Boston, MA, USA*These authors contributed equally to this workCorrespondence: Junjie DengWenzhou Institute, University of Chinese Academy of Sciences, No. 16 Xinsan Road, Hi-Tech Industry Park, Wenzhou, Zhejiang, People’s Republic of ChinaTel +86 577 88017548Fax +86 577 88017554Email [email protected] J WebsterDepartment of Chemical Engineering, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USATel +1 617 373 6585Email [email protected]: Cancer is one of the major causes of death and is difficult to cure using existing clinical therapies. Clinical cancer treatments [such as surgery, chemotherapy (CHT), radiotherapy (RT) and immunotherapy (IT)] are widely used but they have limited therapeutic effects and unavoidable side effects. Recently, the development of novel nanomaterials offers a platform for combinational therapy (meaning a combination of two or more therapeutic agents) which is a promising approach for cancer therapy. Recent studies have demonstrated several types of nanomaterials suitable for photothermal therapy (PTT) based on a near-infrared (NIR) light-responsive system. PTT possesses favorable properties such as being low in cost, and having high temporospatial control with minimal invasiveness. However, short NIR light penetration depth limits its functions.Methods: In this review, due to their promise, we focus on inorganic nanomaterials [such as hollow mesoporous silica nanoparticles (HMSNs), tungsten sulfide quantum dots (WS2QDs), and gold nanorods (AuNRs)] combining PTT with CHT, RT or IT in one treatment, aiming to provide a comprehensive understanding of PTT-based combinational cancer therapy.Results: This review found much evidence for the use of inorganic nanoparticles for PTT-based combinational cancer therapy.Conclusion: Under synergistic effects, inorganic nanomaterial-based combinational treatments exhibit enhanced therapeutic effects compared to PTT, CHT, RT, IT or PDT alone and should be further investigated in the cancer field.Keywords: photothermal agents, hyperthermia, chemotherapy, radiotherapy, immunotherapy, photodynamic therapy
