Nature Communications (May 2019)
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
- Swati Dabral,
- Christian Muecke,
- Chanil Valasarajan,
- Mario Schmoranzer,
- Astrid Wietelmann,
- Gregg L. Semenza,
- Michael Meister,
- Thomas Muley,
- Tamina Seeger-Nukpezah,
- Christos Samakovlis,
- Norbert Weissmann,
- Friedrich Grimminger,
- Werner Seeger,
- Rajkumar Savai,
- Soni S. Pullamsetti
Affiliations
- Swati Dabral
- Department of Lung Development and Remodeling, Member of the German Center for Lung Research (DZL), Max-Planck-Institute for Heart and Lung Research
- Christian Muecke
- Department of Lung Development and Remodeling, Member of the German Center for Lung Research (DZL), Max-Planck-Institute for Heart and Lung Research
- Chanil Valasarajan
- Department of Lung Development and Remodeling, Member of the German Center for Lung Research (DZL), Max-Planck-Institute for Heart and Lung Research
- Mario Schmoranzer
- Department of Lung Development and Remodeling, Member of the German Center for Lung Research (DZL), Max-Planck-Institute for Heart and Lung Research
- Astrid Wietelmann
- MRI and µCT Service Group, Max-Planck-Institute for Heart and Lung Research
- Gregg L. Semenza
- Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, Biological Chemistry, and Genetic Medicine, Johns Hopkins University School of Medicine
- Michael Meister
- Translational Research Unit, Thoraxklinik at Heidelberg University Hospital
- Thomas Muley
- Translational Research Unit, Thoraxklinik at Heidelberg University Hospital
- Tamina Seeger-Nukpezah
- Department I of Internal Medicine and Center for Integrated Oncology, University of Cologne
- Christos Samakovlis
- Department of Lung Development and Remodeling, Member of the German Center for Lung Research (DZL), Max-Planck-Institute for Heart and Lung Research
- Norbert Weissmann
- Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), ECCPS, Member of the DZL, Justus-Liebig University
- Friedrich Grimminger
- Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), ECCPS, Member of the DZL, Justus-Liebig University
- Werner Seeger
- Department of Lung Development and Remodeling, Member of the German Center for Lung Research (DZL), Max-Planck-Institute for Heart and Lung Research
- Rajkumar Savai
- Department of Lung Development and Remodeling, Member of the German Center for Lung Research (DZL), Max-Planck-Institute for Heart and Lung Research
- Soni S. Pullamsetti
- Department of Lung Development and Remodeling, Member of the German Center for Lung Research (DZL), Max-Planck-Institute for Heart and Lung Research
- DOI
- https://doi.org/10.1038/s41467-019-10044-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypertension and a subset of human cancer cells.
