Frontiers in Oncology (Sep 2022)

Is preoperative ultrasound tumor size a prognostic factor in endometrial carcinoma patients?

  • Marco Ambrosio,
  • Antonio Raffone,
  • Antonio Raffone,
  • Andrea Alletto,
  • Chiara Cini,
  • Francesco Filipponi,
  • Daniele Neola,
  • Matilde Fabbri,
  • Alessandro Arena,
  • Alessandro Arena,
  • Diego Raimondo,
  • Paolo Salucci,
  • Manuela Guerrini,
  • Antonio Travaglino,
  • Roberto Paradisi,
  • Antonio Mollo,
  • Renato Seracchioli,
  • Renato Seracchioli,
  • Paolo Casadio

DOI
https://doi.org/10.3389/fonc.2022.993629
Journal volume & issue
Vol. 12

Abstract

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ObjectiveWe aimed to assess the prognostic value of preoperative ultrasound tumor size in EC through a single center, observational, retrospective, cohort study.MethodsMedical records and electronic clinical databases were searched for all consecutive patients with EC, preoperative ultrasound scans available to ad hoc estimate tumor size, and a follow-up of at least 2-year, at our Institution from January 2010 to June 2018. Patients were divided into two groups based on different dimensional cut-offs for the maximum tumor diameter: 2, 3 and 4 cm. Differences in overall survival (OS), disease specific survival (DSS) and progression-free survival (PFS) were assessed among the groups by using the Kaplan–Meier estimator and the log-rank test.Results108 patients were included in the study. OS, DSS and PFS did not significantly differ between the groups based on the different tumor diameter cut-offs. No significant differences were found among the groups sub-stratified by age, BMI, FIGO stage, FIGO grade, lymphovascular space invasion status, myometrial invasion, lymph nodal involvement, histotype, and adjuvant treatment.ConclusionsPreoperative ultrasound tumor size does not appear as a prognostic factor in EC women.

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