Pathophysiology of the coagulation system in general heat injury (scientific and literary review)

Abstract

General unintentional overheating of the body (heat stroke) is a severe life-threatening condition that causes thousands of deaths worldwide every year due to climate changes. Coagulation disorders associated with general heat injury are a determining factor in the course and prognosis of the pathological condition. Coagulopathy is a pathophysiological process that is activated as a result of a systemic inflammatory reaction the basis of which is a destabilized external primary protection of the body against hyperthermia and negative changes in the vascular endothelium. Based on the data of foreign authors and their own clinical experience, the authors were able to highlight certain features and patterns of the development of coagulopathies in thermal trauma.

Keywords

• general overheating of the body
• heat stroke
• coagulopathy
• disseminated intravascular coagulation syndrome
• intensive care