Effect of the Extract of Aloe vera on the Pentylenetetrazol Induced Seizure in Male Mice

Abstract

Background and Objectives: Epilepsy is the most common neurological disorder after stroke. Despite various anticonvulsants, researches continue to discover new drugs with better efficacy and less side-effects. Various herbs and natural substances with different properties are appropriate fields for such researches. This study investigated the effects of Aloe vera latex on seizure in male mice. Methods: Two groups of mice (n=8) and placebo were tested. The control group received Saline and the experimental group received Aloe vera latex (15, 25 and 50mg/kg) and half an hour later PTZ (80mg/kg) was injected intraperitoneally. Immediately after injection of PTZ, seizure threshold and duration of seizure were recorded. Data were analyzed by ANOVA and Tukey's test. p<0.05 was considered statistically significant. Results: The group receiving a 25mg/kg dose of Aloe vera latex showed a significant increase in seizure threshold and a significant decrease in duration of seizure as compared with placebo group receiving saline (p<0.05). Conclusion: The results of this study indicated the anticonvulsant effect of Aloe vera latex.

Keywords

• aloe vera
• pentylenetetrazol
• seizures
• mice