NaOH-Promoted Reduction of Carbonyl Compounds Assisted by Microwave

Abstract

The reduction of aldehydes and ketones based on MPV chemistry is one of the vital transformations in organic chemistry. In this study, MPV chemistry was developed in heating assistance of Microwave to synthesize a broad range of alcohol with yields up to 96 % by a simple, cheap, and safe synthetic protocol. Sodium hydroxide (NaOH) is an excellent promoter for the reduction. The method is quite cheap and straightforward while it utilized easy-to-handle chemicals and did not require strictly anhydrous reagents, transition metals, or any additional ligands. This potential method encourages a scale-up upgrading of Microwave use for alcohol production.