Analytical complex of biochemical markers for preclinical diagnosis and prevention of cardiovascular diseases

Abstract

Due to the achievements of world scientific thought, clinical diagnostic laboratories and diagnostic centers have been given the opportunity to analyze a huge number of biochemical markers of various nature, and their arsenal is replenished from year to year. This article discusses a complex of valid biomarkers, combined for the purpose of biomedical preclinical diagnosis and prevention of cardiovascular diseases. As a justification for the choice of these biochemical markers, we gave trigger processes that underlie the development of cardiovascular pathology, with which selected biochemical markers are associated. The diagnostic complex is based on the “necessity and sufficiency” principle, taking into account financial feasibility, and the ability to measure selected markers in a wide network of clinical diagnostic centers or laboratories. The review is intended to help clinicians with a view to a more detailed understanding of the initial, preclinical stages of cardiovascular diseases, as the most common cause of mortality in Russia, as well as for a wide audience studying or specializing in cardiology.

Keywords

• биохимические маркеры
• сердечно-сосудистые заболевания
• диагностические тесты
• валидация
• доклиническая диагностика