mBio
(Feb 2021)
Signal Recognition Particle Suppressor Screening Reveals the Regulation of Membrane Protein Targeting by the Translation Rate
Liuqun Zhao,
Yanyan Cui,
Gang Fu,
Zixiang Xu,
Xiaoping Liao,
Dawei Zhang
Affiliations
Liuqun Zhao
ORCiD Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
Yanyan Cui
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
Gang Fu
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
Zixiang Xu
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
Xiaoping Liao
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
Dawei Zhang
ORCiD Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
DOI
https://doi.org/10.1128/mBio.02373-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Inner membrane proteins (IMPs) are cotranslationally inserted into the inner membrane or endoplasmic reticulum by the signal recognition particle (SRP). Generally, the deletion of SRP can result in protein targeting defects in Escherichia coli
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