PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

George E. Ronson; Ann Liza Piberger; Martin R. Higgs; Anna L. Olsen; Grant S. Stewart; Peter J. McHugh; Eva Petermann; Nicholas D. Lakin

doi:10.1038/s41467-018-03159-2

Nature Communications (Feb 2018)

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

George E. Ronson,
Ann Liza Piberger,
Martin R. Higgs,
Anna L. Olsen,
Grant S. Stewart,
Peter J. McHugh,
Eva Petermann,
Nicholas D. Lakin

Affiliations

George E. Ronson: Department of Biochemistry, University of Oxford
Ann Liza Piberger: Institute of Cancer and Genomic Sciences, University of Birmingham
Martin R. Higgs: Institute of Cancer and Genomic Sciences, University of Birmingham
Anna L. Olsen: Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford
Grant S. Stewart: Institute of Cancer and Genomic Sciences, University of Birmingham
Peter J. McHugh: Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford
Eva Petermann: Institute of Cancer and Genomic Sciences, University of Birmingham
Nicholas D. Lakin: Department of Biochemistry, University of Oxford

DOI: https://doi.org/10.1038/s41467-018-03159-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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