Chemo-Enzymatic Synthesis, Structural and Stereochemical Characterization, and Intrinsic Degradation Kinetics of Diastereomers of 1‑β‑O‑Acyl Glucuronides Derived from Racemic 2‑{4-[(2-Methylprop-2-en-1-yl)amino]phenyl}propanoic Acid

• Akiko Baba,
• Koki Yamada,
• Takashi Satoh,
• Kazuhiro Watanabe,
• Tadao Yoshioka

Affiliations

Akiko Baba

†Department of Medicinal Chemistry, Hokkaido University of Science, Sapporo, Hokkaido, Japan

Koki Yamada

‡Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Hokkaido, Japan

Takashi Satoh

‡Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Hokkaido, Japan

Kazuhiro Watanabe

‡Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Hokkaido, Japan

Tadao Yoshioka

†Department of Medicinal Chemistry, Hokkaido University of Science, Sapporo, Hokkaido, Japan