The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice

Olivia B. Levine; Mary Jane Skelly; John D. Miller; Jean K. Rivera-Irizarry; Sydney A. Rowson; Jeffrey F. DiBerto; Jennifer A. Rinker; Todd E. Thiele; Thomas L. Kash; Kristen E. Pleil

doi:10.1038/s41467-021-25368-y

Nature Communications (Aug 2021)

The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice

Olivia B. Levine,
Mary Jane Skelly,
John D. Miller,
Jean K. Rivera-Irizarry,
Sydney A. Rowson,
Jeffrey F. DiBerto,
Jennifer A. Rinker,
Todd E. Thiele,
Thomas L. Kash,
Kristen E. Pleil

Affiliations

Olivia B. Levine: Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University
Mary Jane Skelly: Department of Pharmacology, Weill Cornell Medicine, Cornell University
John D. Miller: Department of Pharmacology, Weill Cornell Medicine, Cornell University
Jean K. Rivera-Irizarry: Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University
Sydney A. Rowson: Department of Pharmacology, Weill Cornell Medicine, Cornell University
Jeffrey F. DiBerto: Department of Pharmacology, University of North Carolina-Chapel Hill School of Medicine
Jennifer A. Rinker: Department of Neuroscience, Medical University of South Carolina
Todd E. Thiele: Department of Psychology and Neuroscience, University of North Carolina
Thomas L. Kash: Department of Pharmacology, University of North Carolina-Chapel Hill School of Medicine
Kristen E. Pleil: Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University

DOI: https://doi.org/10.1038/s41467-021-25368-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Bed nucleus of the stria terminalis (BNST) neurons that synthesize and release the stress neuropeptide corticotropin-releasing factor drive binge alcohol drinking and anxiety. The authors describe a complex feedforward inhibitory PVTVGLUT2-BNSTCRF circuit in mice that plays sex-dependent roles in alcohol drinking and avoidance behavior.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal