"Culprit antibody" concept based diagnosis and treatment strategy of autoimmune encephalitis

Abstract

Autoimmune encephalitis (AE) with autoantibodies targeting neuronal surface proteins, ion channels or synaptic surface receptors is a major component of neuroimmune diseases. The detection of autoantibodies is of great value for the diagnosis, treatment and prognosis. Culprit antibody solve the problem of the coexistence of different autoantibodies in the same patient. This article review the relationship between culprit antibody and clinical phenotype in AE.

Keywords

• encephalitis
• autoimmune diseases
• antibodies
• review