Nature Communications (Jul 2019)
ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
- Yuan Tian,
- Bin Yang,
- Weinan Qiu,
- Yajing Hao,
- Zhenxing Zhang,
- Bo Yang,
- Nan Li,
- Shuqun Cheng,
- Zhangjun Lin,
- Yao-cheng Rui,
- Otto K. W. Cheung,
- Weiqin Yang,
- William K. K. Wu,
- Yue-Sun Cheung,
- Paul B. S. Lai,
- Jianjun Luo,
- Joseph J. Y. Sung,
- Runsheng Chen,
- Hong-Yang Wang,
- Alfred S. L. Cheng,
- Pengyuan Yang
Affiliations
- Yuan Tian
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Bin Yang
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Weinan Qiu
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Yajing Hao
- University of Chinese Academy of Sciences
- Zhenxing Zhang
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Bo Yang
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Nan Li
- Eastern Hepatobiliary Surgery Hospital, Second Military Medical University
- Shuqun Cheng
- Eastern Hepatobiliary Surgery Hospital, Second Military Medical University
- Zhangjun Lin
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Yao-cheng Rui
- Department of Pharmacology and School of Pharmacy, Second Military Medical University
- Otto K. W. Cheung
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Weiqin Yang
- School of Biomedical Sciences, The Chinese University of Hong Kong
- William K. K. Wu
- State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong
- Yue-Sun Cheung
- Department of Surgery, The Chinese University of Hong Kong
- Paul B. S. Lai
- Department of Surgery, The Chinese University of Hong Kong
- Jianjun Luo
- Key Laboratory of RNA Biology of CAS, Institute of Biophysics, Chinese Academy of Sciences
- Joseph J. Y. Sung
- State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong
- Runsheng Chen
- Key Laboratory of RNA Biology of CAS, Institute of Biophysics, Chinese Academy of Sciences
- Hong-Yang Wang
- Eastern Hepatobiliary Surgery Hospital, Second Military Medical University
- Alfred S. L. Cheng
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Pengyuan Yang
- Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-019-11274-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Non alcoholic fatty liver disease (NAFLD) associates with an elevated risk of developing hepatocellular carcinoma (HCC). Here, the authors find that Nogo-B, an endoplasmic reticulum resident protein, is upregulated by lipid uptake and acts as an oncogene in NAFLD-associated HCC by promoting lipid droplet breakdown by lipophagy and triggering Hippo pathway dysregulation
