Journal of Inflammation Research (Jan 2023)
The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge
Abstract
Lujian Zhu,1,* Shengnan Luo,1,* Yin Zhu,2 Shiyue Tang,1 Chenge Li,3 Xiaozhi Jin,4 Faling Wu,4 Huimian Jiang,4 Lina Wu,4 Yejin Xu1 1Department of Infectious Diseases, Jinhua Municipal Central Hospital, Jinhua, People’s Republic of China; 2Department of Infectious Diseases, Taizhou Enze Medical Center (Group), Enze Hospital, Taizhou, People’s Republic of China; 3College of Public Health and Management, Wenzhou Medical University, Wenzhou, People’s Republic of China; 4Department of Infectious Diseases, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yejin Xu, Department of Infectious Diseases, Jinhua Municipal Central Hospital, Jinhua, People’s Republic of China, Email [email protected]: Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity caused by glutathione peroxidase 4, the presence of redox-active iron, and the oxidation of phospholipids-containing polyunsaturated fatty acids. In recent years, studies have shown that ferroptosis plays a key role in various liver diseases such as alcoholic liver injury, non-alcoholic steatohepatitis, liver cirrhosis, and liver cancer. However, the mechanism of ferroptosis and its regulation on chronic liver disease are controversial among different types of cells in the liver. Herein, we summarize the current studies on mechanism of ferroptosis in chronic liver disease, aiming to outline the blueprint of ferroptosis as an effective option for chronic liver disease therapy.Keywords: ferroptosis, iron metabolism, liver disease, oxidative stress, cell death
