Nature Communications (May 2021)

High proliferation and delamination during skin epidermal stratification

  • Mareike Damen,
  • Lisa Wirtz,
  • Ekaterina Soroka,
  • Houda Khatif,
  • Christian Kukat,
  • Benjamin D. Simons,
  • Hisham Bazzi

DOI
https://doi.org/10.1038/s41467-021-23386-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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How the developing skin epidermis is transformed from a simple single-layered epithelium to a complex and stratified barrier is still an open question. Here, the authors provide a model based on high proliferation and delamination of the keratinocyte progenitors that support the stratification process.