New Biological Activities of Lythrum salicaria L.: Effects on Keratinocytes, Reconstructed Epidermis and Reconstructed Skins, Applications in Dermo-Cosmetic Sciences

Abstract

The perennial and widespread herb Lythrum salicaria L., also called purple loosestrife, is a plant that is traditionally used in European medicine. Purple loosestrife is known for its ability to treat internal disorders, such as gastrointestinal issues or hemorrhages. Our objective was to take another look on this natural source of ellagitannins in terms of biological activities. Exploration of the phytochemical content of an extract of aerial parts of Lythrum salicaria L. was completed before initiating research on its biological effects towards keratinocytes, reconstructed epidermis, and skins. The potential of the natural compounds were evaluated by topical treatment of reconstructed tissues. The extract and one of its major compounds were able to act as pro-differentiating and protecting agents towards skin cells by stimulating the expressions of markers taking part in the structure of epidermis and dermis. Also, the extract showed beneficial effects on the global morphology of the skin. Thus, Lythrum salicaria L. constitutes a new natural source for the development of active ingredients for the dermo-cosmetic field.

Keywords

• Lythrum salicaria L.
• purple loosestrife
• natural extract
• vescalagin
• skin barrier function
• epidermis
• differentiation
• TGK
• 3D model