Early life experiences selectively mature learning and memory abilities

Abstract

The mechanisms underlying the maturation of learning and memory abilities are poorly understood. Here, authors show that episodic learning produces persistent neuronal activation, BDNF-dependent increase in excitatory synapse markers (synaptophysin and PSD-95), and significant maturation of AMPA receptor synaptic responses in the hippocampus of infant rats and mice compared to juveniles and adults.