Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

Kaixuan Chen; Yurui Jiao; Ling Liu; Mei Huang; Chen He; Wenzhen He; Jing Hou; Mi Yang; Xianghang Luo; Xianghang Luo; Xianghang Luo; Changjun Li; Changjun Li; Changjun Li

doi:10.3389/fcell.2020.598263

Frontiers in Cell and Developmental Biology (Dec 2020)

Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

Kaixuan Chen,
Yurui Jiao,
Ling Liu,
Mei Huang,
Chen He,
Wenzhen He,
Jing Hou,
Mi Yang,
Xianghang Luo,
Xianghang Luo,
Xianghang Luo,
Changjun Li,
Changjun Li,
Changjun Li

Affiliations

Kaixuan Chen: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Yurui Jiao: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Ling Liu: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Mei Huang: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Chen He: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Wenzhen He: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Jing Hou: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Mi Yang: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Xianghang Luo: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Xianghang Luo: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
Xianghang Luo: Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China
Changjun Li: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Changjun Li: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
Changjun Li: Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China

DOI: https://doi.org/10.3389/fcell.2020.598263
Journal volume & issue: Vol. 8

Abstract

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The mammalian skeleton is a metabolically active organ that continuously undergoes bone remodeling, a process of tightly coupled bone resorption and formation throughout life. Recent studies have expanded our knowledge about the interactions between cells within bone marrow in bone remodeling. Macrophages resident in bone (BMMs) can regulate bone metabolism via secreting numbers of cytokines and exosomes. This review summarizes the current understanding of factors, exosomes, and hormones that involved in the communications between BMMs and other bone cells including mensenchymal stem cells, osteoblasts, osteocytes, and so on. We also discuss the role of BMMs and potential therapeutic approaches targeting BMMs in bone remodeling related diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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