Nature Communications (Aug 2021)

Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1

  • Chaoyun Pan,
  • JiHoon Kang,
  • Jung Seok Hwang,
  • Jie Li,
  • Austin C. Boese,
  • Xu Wang,
  • Likun Yang,
  • Titus J. Boggon,
  • Georgia Z. Chen,
  • Nabil F. Saba,
  • Dong M. Shin,
  • Kelly R. Magliocca,
  • Lingtao Jin,
  • Sumin Kang

DOI
https://doi.org/10.1038/s41467-021-24845-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Glucocorticoid receptor (GR) agonists - used in the treatment of solid malignant tumors to reduce inflammation - could potentially affect the anti-tumor activity of chemotherapy. Here, the authors identify a mechanism of cisplatin resistance observed with GR agonist treatment, and show the binding and activation of GR by cisplatin, which leads to MAST1 activation and subsequent MAPK re-activation.