Clinicopathological significance of HSP27 in gastric cancer: a meta-analysis
OncoTargets and Therapy. 2017;Volume 10:4543-4551
Journal Title: OncoTargets and Therapy
ISSN: 1178-6930 (Online)
Publisher: Dove Medical Press
LCC Subject Category: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Country of publisher: United Kingdom
Language of fulltext: English
Full-text formats available: PDF, HTML
AUTHORS
Ge H
He X
Guo L
Yang X
EDITORIAL INFORMATION
Time From Submission to Publication: 16 weeks
Abstract | Full Text
Hua Ge, Xueyan He, Lingfei Guo, Xianzhi Yang Department of Gastrointestinal Surgery, The First People’s Hospital of Zunyi, Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China Background: Many studies have provided increasing evidence to demonstrate that HSP27 has been involved in the development of gastric cancer; however, they all include few patients and the results remain controversial. Hence, we conducted a meta-analysis to evaluate correlations between HSP27 and the clinicopathological characteristics of gastric cancer.Methods: An electronic search for relevant articles was conducted in PubMed, Cochrane Library, Web of Science, EMBASE database, Chinese CNKI, and Wan Fang. Data on the relationship between HSP27 expression and lymph node metastasis, serosal invasion, gender, tumor size, differentiation, and TNM stage were extracted. Pooled odds ratios and 95% confidence intervals were estimated by forest plot.Results: The pooled analyses suggested that HSP27 expression was significantly associated with the incidence of gastric cancer. However, HSP27 expression had no significant relationship with lymph node metastasis, serosal invasion, gender, tumor size, differentiation, and TNM stage.Conclusion: Our meta-analysis demonstrated that HSP27 may play vital roles in tumorigenesis and deterioration of gastric cancer. However, further high-quality studies are needed to provide more reliable evidence. Keywords: heat shock protein 27, gastric cancer, meta-analysis