Nature Communications (Apr 2019)

Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM

  • Huidong Chen,
  • Luca Albergante,
  • Jonathan Y. Hsu,
  • Caleb A. Lareau,
  • Giosuè Lo Bosco,
  • Jihong Guan,
  • Shuigeng Zhou,
  • Alexander N. Gorban,
  • Daniel E. Bauer,
  • Martin J. Aryee,
  • David M. Langenau,
  • Andrei Zinovyev,
  • Jason D. Buenrostro,
  • Guo-Cheng Yuan,
  • Luca Pinello

DOI
https://doi.org/10.1038/s41467-019-09670-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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The increasing accessibility of single cell omics technologies beyond transcriptomics demands parallel advances in analysis. Here, the authors introduce STREAM, a pipeline for reconstruction and visualization of differentiation trajectories from both single-cell RNA-seq and ATAC-seq data.