Архивъ внутренней медицины (Feb 2018)

CHRONIC HEPATITIS B AND C IN WOMEN: COURSE OF PREGNANCY, DELIVERY AND MORPHOLOGICAL CHARACTERISTICS OF THE PLACENTA

  • M. A. Belopolskaya,
  • V. Yu. Avrutin,
  • E. A. Rukoiatkina,
  • A. V. Dmitriev

DOI
https://doi.org/10.20514/2226-6704-2018-8-1-22-28
Journal volume & issue
Vol. 8, no. 1
pp. 22 – 28

Abstract

Read online

Despite the widespread prevalence of chronic hepatitis all over the world, the impact of these diseases on the pregnancy course and on the childbirth is still insufficiently investigated. Recently, some studies have been published, discussing the relationship between the state of the placenta and the risk of the mother to child transmission of hepatitis. The aim of this work was to make a comparative analysis of the features of pregnancy in women with chronic hepatitis B and C (CHB and CHC, respectively), to evaluate the relationship between inflammatory changes in the placenta and the frequency of hepatitis markers detection in cord blood. In this work we present a retrospective analysis of the birth histories of randomly selected women with chronic hepatitis which gave birth in the maternity hospital No. 16 in St. Petersburg. In total, 35 pregnant women with CHB and 36 pregnant women with CHC were included in this study. Excluded from the study were women with co-infections, cirrhosis and severe concomitant diseases. The studied groups had no significant differences in the age, weight and height, as well as in the number of pregnancies and childbirths in the anamnesis. According to the results of our study, there were no significant differences in the state of newborns from the mothers with CHB and CHC. According to our data, anemia during pregnancy occurred significantly more frequently in women with CHB than with CHC. It has been shown that in both groups, the choriodeciduitis was observed in almost a half of the women. Remarkably, the frequency of premature rupture of membrane in both groups was significantly higher than the average in the population. In addition, a reliable relationship between inflammatory changes in the placenta and the detection of HBsAg in the cord blood was revealed. This relationship suggests that in women with inflammatory changes in the placenta, the risk of hepatitis B vertical transmission may be higher.

Keywords