Nature Communications (Jan 2020)

No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1

  • Albertas Navickas,
  • Sébastien Chamois,
  • Rénette Saint-Fort,
  • Julien Henri,
  • Claire Torchet,
  • Lionel Benard

DOI
https://doi.org/10.1038/s41467-019-13991-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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In the No-Go decay mRNA surveillance pathway, mRNAs containing stalled ribosomes are cleaved by an endoribonuclease. Here the authors show the endonucleolytic cleavage on the artificial No-Go decay target mRNAs, revealing downstream decay process by Trl1 kinase and the 5′ to 3′ exonuclease Dxo1.