Stress promotes RNA G-quadruplex folding in human cells

Prakash Kharel; Marta Fay; Ekaterina V. Manasova; Paul J. Anderson; Alexander V. Kurkin; Junjie U. Guo; Pavel Ivanov

doi:10.1038/s41467-023-35811-x

Nature Communications (Jan 2023)

Stress promotes RNA G-quadruplex folding in human cells

Prakash Kharel,
Marta Fay,
Ekaterina V. Manasova,
Paul J. Anderson,
Alexander V. Kurkin,
Junjie U. Guo,
Pavel Ivanov

Affiliations

Prakash Kharel: Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Marta Fay: Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Ekaterina V. Manasova: Chemistry Department of Lomonosov Moscow State University
Paul J. Anderson: Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Alexander V. Kurkin: Chemistry Department of Lomonosov Moscow State University
Junjie U. Guo: Department of Neuroscience, Yale School of Medicine
Pavel Ivanov: Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-023-35811-x
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 10

Abstract

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rG4s are G-quadruplex structures found in transcriptome. Many RNAs can fold into rG4s in vitro, yet their folding and functions in vivo are not well understood. Here the authors showed that rG4s folding is dynamically regulated under stress in human cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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