Nature Communications (Nov 2021)

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

  • Ryan J. Geusz,
  • Allen Wang,
  • Dieter K. Lam,
  • Nicholas K. Vinckier,
  • Konstantinos-Dionysios Alysandratos,
  • David A. Roberts,
  • Jinzhao Wang,
  • Samy Kefalopoulou,
  • Araceli Ramirez,
  • Yunjiang Qiu,
  • Joshua Chiou,
  • Kyle J. Gaulton,
  • Bing Ren,
  • Darrell N. Kotton,
  • Maike Sander

DOI
https://doi.org/10.1038/s41467-021-26950-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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Enhancers for endodermal organs are primed at the chromatin level prior to lineage induction by FOXA pioneer transcription factors; how pervasive this is, is not well known. Here the authors show that only a small subset of organ-specific enhancers are bound and primed by FOXA prior to lineage induction, whereas the majority do not undergo chromatin priming and engage FOXA upon lineage induction.