Case report: radiation-induced lumbosacral plexopathy – a very late complication of radiotherapy for cervical cancer
Peter Krkoska,
Tomas Kazda,
Daniela Vlazna,
Blanka Adamova
Affiliations
Peter Krkoska
Department of Neurology, Center for Neuromuscular Diseases (Associated National Center in the European Reference Network ERN EURO-NMD), University Hospital Brno
Tomas Kazda
Faculty of Medicine, Masaryk University
Daniela Vlazna
Department of Neurology, Center for Neuromuscular Diseases (Associated National Center in the European Reference Network ERN EURO-NMD), University Hospital Brno
Blanka Adamova
Department of Neurology, Center for Neuromuscular Diseases (Associated National Center in the European Reference Network ERN EURO-NMD), University Hospital Brno
Abstract Background Lumbosacral plexopathy caused by radiotherapy is a rare but severe consequence of cancer treatment. This condition often leads to varying degrees of sensory and motor impairment. Neurological complications, which are typically permanent, manifest a long period after irradiation. Case presentation We describe a case of progressive lower extremity weakness and sensory impairment in a woman who had been effectively treated with radiotherapy for cervical cancer with development 36 years after irradiation. The electrophysiological assessment revealed a subacute bilateral axonal lesion of the lumbosacral plexus. None of the clinical manifestations, serology, cerebrospinal fluid or imaging data discovered an explanation other than radiation-induced lumbosacral plexopathy (RILP). Conclusions This case demonstrates that RILP may emerge more than 30 years after the radiotherapy.
