SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase

Cassandra B. Higgins; Allyson L. Mayer; Yiming Zhang; Michael Franczyk; Samuel Ballentine; Jun Yoshino; Brian J. DeBosch

doi:10.1038/s41467-022-28717-7

Nature Communications (Feb 2022)

SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase

Cassandra B. Higgins,
Allyson L. Mayer,
Yiming Zhang,
Michael Franczyk,
Samuel Ballentine,
Jun Yoshino,
Brian J. DeBosch

Affiliations

Cassandra B. Higgins: Department of Pediatrics, Washington University School of Medicine
Allyson L. Mayer: Biogenerator
Yiming Zhang: Department of Pediatrics, Washington University School of Medicine
Michael Franczyk: Department of Medicine, Keio University School of Medicine
Samuel Ballentine: Department of Anatomic and Molecular Pathology, Washington University School of Medicine
Jun Yoshino: Department of Medicine, Keio University School of Medicine
Brian J. DeBosch: Department of Pediatrics, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-28717-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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NAD + metabolism is potential target to treat metabolic disorders, in part due to the effects of the NAD + dependent enzyme Sirt1. Here the authors report that hepatic nicotinamide phosphoribosyltransferase, a rate-limiting step in the NAD + salvage pathway, regulates dark-cycle thermogenesis in a Sirt1-dependent but light-cycle thermogenesis and glucose homeostasis in a Sirt1-independent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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