CEREBRAL CIRCULATION AND COGNITION IN PATIENTS WITH CORONARY HEART DISEASE UNDERWENT CORONARY BYPASS OPERATION

Abstract

Aim. To assess the condition of cerebral circulation and cognitive functions in patients with coronary heart disease (CHD), underwent coronary bypass (CBG) operation under on-pump conditions and to evaluate the influence of citicoline on the higher brain functions at earlier and delayed periods post-surgery.Material and methods. In the Federal center of cardiosurgery (Krasnoyarsk city) 66 patients studied, with diagnosis CHD. Patients selected to 2 groups. Main group (n=36) as a medium for cerebral neuroprotection we used citicoline (Ceraxon): intravenous, 1 day before surgery, 1000 mg on 200 mL of saline, and then for 7 days after surgery, with further intake of the drug 900 mg/daily for 2 months. In comparison group (n=30) there was no neuroprotection in peri-operation period. Results. By the 12th month after surgery, cognition returned to baseline values. In controls, by 12 months after CBG, cognition returned to baseline only by the test “visual memory” of 5 words (direct remembering).Conclusion. Neuroprotection by citicoline might be a method for improvement of cognition in patients after such damaging events as on-pump operation, and therefore make it to reach higher level of daily functioning of post-CBG patients.

Keywords

• coronary heart disease
• cognition impairment
• coronary bypass
• transcranial doppler study