Anais da Academia Brasileira de Ciências (Aug 2023)

Tracheal regeneration with acellular human amniotic membrane and 15-deoxy-∆12,14prostaglandinj2 nanoparticles in a rabbit model

  • ANNA FLAVIA R.S. MIGGIOLARO,
  • ALINE L. TAKEJIMA,
  • JULIO CESAR FRANCISCO,
  • LÚCIA DE NORONHA,
  • MILKA L. TAKEJIMA,
  • KATIA FOLTZ,
  • ALOYSIO ENCK,
  • LUANA TANNOUS,
  • ROSSANA B. SIMEONI,
  • PRISCILA E.F. STRICKER,
  • KATHERINE A.T. CARVALHO,
  • LUIZ CESAR GUARITA-SOUZA

DOI
https://doi.org/10.1590/0001-3765202320220288
Journal volume & issue
Vol. 95, no. suppl 1

Abstract

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Abstract The treatment of tracheal pathologies remains challenging.Nanotechnology allows adding substances to decellularized human amniotic membrane (DHAM), such as 15-Deoxy-∆12,14ProstaglandinJ2 nanoparticles (15D-PGJ2-NC).This study performed a tracheotomy in rabbits randomized into three groups.The tissue repair process was evaluated when treated with DHAM associated or not with 15D-PGJ2-NC.The average of the area in the control group was 54.76% smaller than DHAM group and 41.98% smaller than DHAM + 15D-PGJ2-NC group (p=0.004 for both).The DHAM + 15D-PGJ2-NC group had significantly more immature cartilage (p=0.015).DHAM impregnated with 15D-PGJ2-NC could provide support for the healing of the tracheal defect and may prevent reduction of its lumen.

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