Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth

Teruo Kusano; Driss Ehirchiou; Tomohiro Matsumura; Veronique Chobaz; Sonia Nasi; Mariela Castelblanco; Alexander So; Christine Lavanchy; Hans Acha-Orbea; Takeshi Nishino; Ken Okamoto; Nathalie Busso

doi:10.1038/s41467-019-12565-z

Nature Communications (Oct 2019)

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth

Teruo Kusano,
Driss Ehirchiou,
Tomohiro Matsumura,
Veronique Chobaz,
Sonia Nasi,
Mariela Castelblanco,
Alexander So,
Christine Lavanchy,
Hans Acha-Orbea,
Takeshi Nishino,
Ken Okamoto,
Nathalie Busso

Affiliations

Teruo Kusano: Department of Biochemistry and Molecular Biology, Nippon Medical School
Driss Ehirchiou: Department of Biochemistry CIIL, University of Lausanne
Tomohiro Matsumura: Department of Biochemistry and Molecular Biology, Nippon Medical School
Veronique Chobaz: DAL, Service of Rheumatology, Laboratory of Rheumatology, University of Lausanne, CHUV
Sonia Nasi: DAL, Service of Rheumatology, Laboratory of Rheumatology, University of Lausanne, CHUV
Mariela Castelblanco: DAL, Service of Rheumatology, Laboratory of Rheumatology, University of Lausanne, CHUV
Alexander So: DAL, Service of Rheumatology, Laboratory of Rheumatology, University of Lausanne, CHUV
Christine Lavanchy: Department of Biochemistry CIIL, University of Lausanne
Hans Acha-Orbea: Department of Biochemistry CIIL, University of Lausanne
Takeshi Nishino: Department of Biochemistry and Molecular Biology, Nippon Medical School
Ken Okamoto: Department of Biochemistry and Molecular Biology, Nippon Medical School
Nathalie Busso: DAL, Service of Rheumatology, Laboratory of Rheumatology, University of Lausanne, CHUV

DOI: https://doi.org/10.1038/s41467-019-12565-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The roles of the convertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO) during tumorigenesis is not known. Here, the authors develop XDH-stable and XO-locked knock-in (ki) mice and show increased tumor growth in XO ki mice, via macrophage-mediated immunoregulatory responses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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