Nature Communications (Oct 2022)
Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease
- Letizia De Chiara,
- Carolina Conte,
- Roberto Semeraro,
- Paula Diaz-Bulnes,
- Maria Lucia Angelotti,
- Benedetta Mazzinghi,
- Alice Molli,
- Giulia Antonelli,
- Samuela Landini,
- Maria Elena Melica,
- Anna Julie Peired,
- Laura Maggi,
- Marta Donati,
- Gilda La Regina,
- Marco Allinovi,
- Fiammetta Ravaglia,
- Daniele Guasti,
- Daniele Bani,
- Luigi Cirillo,
- Francesca Becherucci,
- Francesco Guzzi,
- Alberto Magi,
- Francesco Annunziato,
- Laura Lasagni,
- Hans-Joachim Anders,
- Elena Lazzeri,
- Paola Romagnani
Affiliations
- Letizia De Chiara
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Carolina Conte
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Roberto Semeraro
- Department of Experimental and Clinical Medicine, University of Florence
- Paula Diaz-Bulnes
- Translational immunology, Instituto de Investigación Sanitaria del Principado de Asturias ISPA
- Maria Lucia Angelotti
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Benedetta Mazzinghi
- Nephrology and Dialysis Unit, Meyer Children’s University Hospital
- Alice Molli
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Giulia Antonelli
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Samuela Landini
- Medical Genetics Unit, Meyer Children’s University Hospital
- Maria Elena Melica
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Anna Julie Peired
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Laura Maggi
- Department of Experimental and Clinical Medicine, University of Florence
- Marta Donati
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Gilda La Regina
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Marco Allinovi
- Nephrology, Dialysis and Transplantation Unit, Careggi University Hospital
- Fiammetta Ravaglia
- Nephrology and Dialysis Unit, Santo Stefano Hospital
- Daniele Guasti
- Department of Experimental & Clinical Medicine, Imaging Platform, University of Florence
- Daniele Bani
- Department of Experimental & Clinical Medicine, Imaging Platform, University of Florence
- Luigi Cirillo
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Francesca Becherucci
- Nephrology and Dialysis Unit, Meyer Children’s University Hospital
- Francesco Guzzi
- Nephrology and Dialysis Unit, Santo Stefano Hospital
- Alberto Magi
- Department of Information Engineering, University of Florence
- Francesco Annunziato
- Department of Experimental and Clinical Medicine, University of Florence
- Laura Lasagni
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Hans-Joachim Anders
- Division of Nephrology, Department of Internal Medicine IV, LMU Hospital
- Elena Lazzeri
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- Paola Romagnani
- Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
- DOI
- https://doi.org/10.1038/s41467-022-33110-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Acute kidney injury is frequent, often fatal and can leave survivors with chronic kidney disease. Here the authors show that tubular cell polyploidy reduces early fatality sustaining residual function but promotes chronic kidney disease, which can be prevented by blocking YAP1
