Endogenous Retroviruses in Nervous System Disorders

Victoria Gröger; Alexander Emmer; Martin S. Staege; Holger Cynis

doi:10.3390/ph14010070

Pharmaceuticals (Jan 2021)

Endogenous Retroviruses in Nervous System Disorders

Victoria Gröger,
Alexander Emmer,
Martin S. Staege,
Holger Cynis

Affiliations

Victoria Gröger: Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology, 06120 Halle (Saale), Germany
Alexander Emmer: Department of Neurology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany
Martin S. Staege: Department of Surgical and Conservative Pediatrics and Adolescent Medicine, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany
Holger Cynis: Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology, 06120 Halle (Saale), Germany

DOI: https://doi.org/10.3390/ph14010070
Journal volume & issue: Vol. 14, no. 1
p. 70

Abstract

Read online

Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies.

Published in Pharmaceuticals

ISSN: 1424-8247 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceuticals/

About the journal

Abstract

Keywords