Disseminated tuberculosis, CMV viraemia &amp; haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies – case report and brief review

G.I. Butel-Simoes; C. Kiss; K. Kong; L.B. Rosen; L.M. Hosking; S. Barnes; G.A. Jenkin; S. Megaloudis; B. Kumar; S.M. Holland; S. Ojaimi

Clinical Immunology Communications (Dec 2023)

Disseminated tuberculosis, CMV viraemia & haemophagocytic-lymphohistiocystosis syndrome in an adult patient with anti- IFNγ autoantibodies – case report and brief review

G.I. Butel-Simoes,
C. Kiss,
K. Kong,
L.B. Rosen,
L.M. Hosking,
S. Barnes,
G.A. Jenkin,
S. Megaloudis,
B. Kumar,
S.M. Holland,
S. Ojaimi

Affiliations

G.I. Butel-Simoes: Monash Infectious Diseases, Monash Health, Victoria, Australia
C. Kiss: Monash Infectious Diseases, Monash Health, Victoria, Australia
K. Kong: Monash Infectious Diseases, Monash Health, Victoria, Australia
L.B. Rosen: Immunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, United States
L.M. Hosking: Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Victoria, Australia; Immunology Laboratory, Laboratory Services, Royal Children's Hospital, Parkville, Victoria, Australia
S. Barnes: Monash Lung Sleep Allergy Immunology, Monash Health, Victoria, Australia; Monash University Department of Medicine, Monash University, Victoria, Australia
G.A. Jenkin: Monash Infectious Diseases, Monash Health, Victoria, Australia
S. Megaloudis: Haematology Laboratory, Monash Pathology, Monash Health, Victoria, Australia
B. Kumar: Anatomical Pathology Laboratory, Monash Pathology, Monash Health, Victoria, Australia
S.M. Holland: Immunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, United States
S. Ojaimi: Monash Infectious Diseases, Monash Health, Victoria, Australia; Monash Lung Sleep Allergy Immunology, Monash Health, Victoria, Australia; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Victoria, Australia; Immunology Laboratory, Monash Pathology, Monash Health, Victoria, Australia; Corresponding author.

Journal volume & issue: Vol. 4
pp. 55 – 59

Abstract

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We report a case of an adult female with disseminated tuberculosis, cytomegalovirus viraemia and haemophagocytic-lymphohistiocystosis syndrome associated with neutralizing anti- interferon gamma (IFNγ) autoantibodies demonstrated by absent IFNγ stimulated STAT1 phosphorylation in the presence of patient sera. A brief review of immunodeficiency caused by anti-IFNγ autoantibodies is also described.

Published in Clinical Immunology Communications

ISSN: 2772-6134 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.journals.elsevier.com/clinical-immunology-communications

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