Nature Communications (Jan 2023)
Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus
- Anna M. Sigmund,
- Markus Winkler,
- Sophia Engelmayer,
- Daniela Kugelmann,
- Desalegn T. Egu,
- Letyfee S. Steinert,
- Michael Fuchs,
- Matthias Hiermair,
- Mariya Y. Radeva,
- Franziska C. Bayerbach,
- Elisabeth Butz,
- Stefan Kotschi,
- Christoph Hudemann,
- Michael Hertl,
- Sunil Yeruva,
- Enno Schmidt,
- Amir S. Yazdi,
- Kamran Ghoreschi,
- Franziska Vielmuth,
- Jens Waschke
Affiliations
- Anna M. Sigmund
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Markus Winkler
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Sophia Engelmayer
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Daniela Kugelmann
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Desalegn T. Egu
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Letyfee S. Steinert
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Michael Fuchs
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Matthias Hiermair
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Mariya Y. Radeva
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Franziska C. Bayerbach
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Elisabeth Butz
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Stefan Kotschi
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Christoph Hudemann
- Department of Dermatology and Allergology, Philipps-University Marburg
- Michael Hertl
- Department of Dermatology and Allergology, Philipps-University Marburg
- Sunil Yeruva
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Enno Schmidt
- Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck
- Amir S. Yazdi
- Department of Dermatology, Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) Aachen University
- Kamran Ghoreschi
- Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin
- Franziska Vielmuth
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- Jens Waschke
- Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich
- DOI
- https://doi.org/10.1038/s41467-022-35741-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies which destabilize cell adhesion of keratinocytes. The phosphodiesterase 4 inhibitor apremilast prevents skin blistering by stabilizing the keratin filament anchorage of desmosomes.
