Nature Communications (Feb 2022)

Structural basis of neuropeptide Y signaling through Y1 receptor

  • Chaehee Park,
  • Jinuk Kim,
  • Seung-Bum Ko,
  • Yeol Kyo Choi,
  • Hyeongseop Jeong,
  • Hyeonuk Woo,
  • Hyunook Kang,
  • Injin Bang,
  • Sang Ah Kim,
  • Tae-Young Yoon,
  • Chaok Seok,
  • Wonpil Im,
  • Hee-Jung Choi

DOI
https://doi.org/10.1038/s41467-022-28510-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention. Here, the authors show that, unlike in other neuropeptides, both the N-terminal and the C-terminal regions of NPY interact with the NPY receptor 1.