Marine Drugs (Jun 2014)

Cespitulones A and B, Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata

  • Yu-Chi Lin,
  • Shih-Sheng Wang,
  • Chung-Hsiung Chen,
  • Yao-Haur Kuo,
  • Ya-Ching Shen

DOI
https://doi.org/10.3390/md12063477
Journal volume & issue
Vol. 12, no. 6
pp. 3477 – 3486

Abstract

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Two novel diterpenoids, cespitulones A (1) and B (2), were isolated from extracts of the soft coral Cespitularia taeniata. Both compounds possess an unprecedented bicyclo [10.3.1] ring system with C-C bond connections between C-10 and C-20, and between C-20 and C-11. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 1 exhibited significant cytotoxicity against human medulloblastoma and colon adenocarcinoma cancer cells.

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