Nature Communications (Oct 2017)

High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidation

  • Yong Yu,
  • Ayse Sena Mutlu,
  • Harrison Liu,
  • Meng C. Wang

DOI
https://doi.org/10.1038/s41467-017-00944-3
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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High-throughput genetic screens in animals could benefit from an easy way to mark positive hits. Here the authors introduce photo-highlighting using a photoconvertible fluorescent protein, and in combination with stimulated Raman scattering (SRS) microscopy, define a role for BMP signaling in lipid metabolism in C. elegans.