Frontiers in Endocrinology (Apr 2023)

Clinical application of 18F-FCH PET/CT in the diagnosis and treatment of hyperparathyroidism

  • Shuang Liu,
  • Mengdan Li,
  • Hua Pang,
  • Rui Zuo,
  • Lingquan Kong,
  • Zhengjie Wang,
  • Wenbo Li,
  • Zhu Xia,
  • Dong Wang,
  • Lu Xu

DOI
https://doi.org/10.3389/fendo.2023.1100056
Journal volume & issue
Vol. 14

Abstract

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ObjectiveWe evaluated the difference in parathyroid visualization on 18F-FCH PET/CT images obtained at 5 and 60 min, and quantitatively analyzed the mode of FCH uptake at different time points, to determine the best imaging time for FCH PET/CT.MethodsThis retrospective study included 73 patients with hyperparathyroidism (HPT) who underwent 18F-FCH PET/CT imaging between December 2017 and December 2021. The diagnostic efficiency of 5- and 60-min dual time point imaging for the diagnosis of hyperparathyroidism and parathyroid adenoma and hyperplasia, were compared using visual and quantitative analyses.ResultsDual-time 18F-FCH PET/CT imaging visual analysis had diagnostic value for HPT. The receiver operating characteristic curve of PET/CT quantitative parameters for the diagnosis of HPT and lesions showed that the parathyroid/thyroid SUVmax ratio for 60-min imaging had a higher sensitivity and specificity (based on patient, sensitivity: 90.90% and specificity: 85.71%; based on focus, sensitivity: 83.06% and specificity: 85.71%) compared to that for 5-min imaging. PET/CT quantitative parameters can distinguish parathyroid adenoma and hyperplasia. The 60-min parathyroid SUVmax value had the highest diagnostic value (cutoff: 3.945; area under the curve: 0.783).ConclusionThe quantitative parameters of 60min 18F-FCH PET/CT have more advantages in aiding in the pathologica diagnosis and clinical treatment of HPT.

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