Molecular Cytogenetics (May 2012)

Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review

  • Hu Xiaoxia,
  • Chen Haiying,
  • Jin Meishan,
  • Wang Xianfu,
  • Lee Jiyun,
  • Xu Weihong,
  • Zhang Rui,
  • Li Shibo,
  • Niu Junqi

DOI
https://doi.org/10.1186/1755-8166-5-26
Journal volume & issue
Vol. 5, no. 1
p. 26

Abstract

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Abstract Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.

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