S100 proteins in mammary gland regulation and their role in breast cancer metastasis

Abstract

S100 proteins have emerged as key regulators in the mammary gland and have been implicated in breast cancer development and metastasis. This review provides a comprehensive overview of the roles of S100 proteins in mammary gland regulation and their impact on breast cancer progression. The mammary gland, a complex organ involved in lactation and tissue homeostasis, undergoes dynamic changes during different physiological stages. S100 proteins play crucial roles in mammary gland development, differentiation, and function, participating in cellular processes such as proliferation, migration, and apoptosis. However, dysregulation of S100 proteins can contribute to breast cancer initiation and metastasis. These proteins are involved in angiogenesis, invasion, migration, and epithelial-mesenchymal transition, promoting aggressive behavior in breast cancer cells. Understanding the intricate mechanisms by which S100 proteins exert their effects in the mammary gland and breast cancer is crucial for the development of targeted therapies and identification of diagnostic and prognostic biomarkers. Further research in this field will provide valuable insights and potential advancements in breast cancer management. This review highlights the significance of unraveling the role of S100 proteins in mammary gland regulation and their impact on breast cancer metastasis.

Keywords

• S100 protein family
• Breast cancer
• Mammary gland development
• Signalling
• Ligand-receptor interaction
• Therapeutic target