Evaluation of Potential Effect of Bone Marrow Mast Cells on Burn Wound Healing in Rat

Abstract

The objective of this work was to assess the potential effect of bone marrow mast cells (BMMCs) on burn wound healing in rats. We included 45 male rats into three groups of 15 animals each: CNTRL group: We treated the burn wounds with normal saline (0.1 ml). TRTMENT group: In this group, the burn wounds were treated with bone marrow mast cells (1× 106/ml). SSD (Positive control) group: In this group, the wounds were treated with silver sulfadiazine 1% ointment. Wound area reduction measurements, histopathological studies, and biochemical assessments levels showed significant differences between rats in TRTMENT group in comparison with other groups (p < 0.05). Accelerated repair of the wounds in TRTMENT group showed that local application of BMMCs could be taken into consideration in burn wound healing.

Keywords

• burn wound
• bmmcs
• rat