Nature Communications (Oct 2019)

NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains

  • Priscillia Lhoumaud,
  • Sana Badri,
  • Javier Rodriguez-Hernaez,
  • Theodore Sakellaropoulos,
  • Gunjan Sethia,
  • Andreas Kloetgen,
  • MacIntosh Cornwell,
  • Sourya Bhattacharyya,
  • Ferhat Ay,
  • Richard Bonneau,
  • Aristotelis Tsirigos,
  • Jane A. Skok

DOI
https://doi.org/10.1038/s41467-019-12811-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 18

Abstract

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In multiple myeloma, a 4;14 translocation induces overexpression of histone methyltransferase NSD2, resulting in expansion of H3K36me2 and shrinkage of H3K27me3 domains. Here the authors find that CTCF, H3K27ac and gene expression changes cluster within a subset of insulated domains implicating 3D chromosome organization as a key factor in the NSD2-mediated phenotype.