Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor

Junke Liu; Hengmin Tang; Chanjuan Xu; Shengnan Zhou; Xunying Zhu; Yuanyuan Li; Laurent Prézeau; Tao Xu; Jean-Philippe Pin; Philippe Rondard; Wei Ji; Jianfeng Liu

doi:10.1038/s41467-022-34056-4

Nature Communications (Oct 2022)

Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor

Junke Liu,
Hengmin Tang,
Chanjuan Xu,
Shengnan Zhou,
Xunying Zhu,
Yuanyuan Li,
Laurent Prézeau,
Tao Xu,
Jean-Philippe Pin,
Philippe Rondard,
Wei Ji,
Jianfeng Liu

Affiliations

Junke Liu: Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology
Hengmin Tang: Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology
Chanjuan Xu: Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology
Shengnan Zhou: Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology
Xunying Zhu: Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology
Yuanyuan Li: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Laurent Prézeau: Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM
Tao Xu: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Jean-Philippe Pin: Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM
Philippe Rondard: Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM
Wei Ji: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Jianfeng Liu: Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-022-34056-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internalization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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