Cesium carbonate mediated exclusive dialkylation of active methylene compounds

Abstract

Active methylene compounds are regioselectively dialkylated by variety of alkyl halides using cesium carbonate in quantitative yield. The reaction yielded exclusively dialkylated products with no intermediate monoalkyaltion or mixture of products.

Keywords

• Balanced base
• Aprotic solvent
• Active methylene compounds
• Reactive halides
• Complete conversion