Journal of King Saud University: Science (Apr 2014)

Triphenylphosphine: An efficient catalyst for the synthesis of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione under thermal conditions

  • K. Aswin,
  • S. Sheik Mansoor,
  • K. Logaiya,
  • S.P.N. Sudhan

DOI
https://doi.org/10.1016/j.jksus.2013.05.004
Journal volume & issue
Vol. 26, no. 2
pp. 141 – 148

Abstract

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An efficient and direct procedure for the synthesis of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione derivatives by condensation of 1,3-diaryl-2-propen-1-ones (chalcones) and thiourea in ethanol at 65 °C using triphenylphosphine (PPh3) as a catalyst is reported. The method gave good yields of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione derivatives in short reaction times in comparison with earlier methods. The catalyst is recycled without loss of activity. Using non-toxic and inexpensive materials, simple work-up, short reaction times and high yields of the products are the advantages of this method.

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