Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion

Yuzuna Aoki, MD; Masayuki Maeda, MD, PhD; Seiya Kishi, MD; Ryota Kogue, MD, PhD; Fumine Tanaka, MD; Maki Umino, MD, PhD; Mami Takeoka, MD; Ryo Hanaki, MD, PhD; Junya Hirayama, MD, PhD; Hiroto Yuasa, MD; Hiroshi Imai, MD, PhD; Masahiro Hirayama, MD, PhD; Hajime Sakuma, MD, PhD

Radiology Case Reports (Oct 2022)

Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion

Yuzuna Aoki, MD,
Masayuki Maeda, MD, PhD,
Seiya Kishi, MD,
Ryota Kogue, MD, PhD,
Fumine Tanaka, MD,
Maki Umino, MD, PhD,
Mami Takeoka, MD,
Ryo Hanaki, MD, PhD,
Junya Hirayama, MD, PhD,
Hiroto Yuasa, MD,
Hiroshi Imai, MD, PhD,
Masahiro Hirayama, MD, PhD,
Hajime Sakuma, MD, PhD

Affiliations

Yuzuna Aoki, MD: Department of Radiology, Mie University School of Medicine, Tsu, Mie, Japan
Masayuki Maeda, MD, PhD: Department of Neuroradiology, Mie University School of Medicine, 2-174 Edobashi, Tsu 514-8507, Mie, Japan; Corresponding author.
Seiya Kishi, MD: Department of Radiology, Mie University School of Medicine, Tsu, Mie, Japan
Ryota Kogue, MD, PhD: Department of Radiology, Mie University School of Medicine, Tsu, Mie, Japan
Fumine Tanaka, MD: Department of Radiology, Mie University School of Medicine, Tsu, Mie, Japan
Maki Umino, MD, PhD: Department of Radiology, Mie University School of Medicine, Tsu, Mie, Japan
Mami Takeoka, MD: Department of Pediatrics, Mie University School of Medicine, Tsu, Mie, Japan
Ryo Hanaki, MD, PhD: Department of Pediatrics, Mie University School of Medicine, Tsu, Mie, Japan
Junya Hirayama, MD, PhD: Department of Pediatrics, Mie University School of Medicine, Tsu, Mie, Japan
Hiroto Yuasa, MD: Pathology Division, Mie University Hospital, Tsu, Mie, Japan
Hiroshi Imai, MD, PhD: Pathology Division, Mie University Hospital, Tsu, Mie, Japan
Masahiro Hirayama, MD, PhD: Department of Pediatrics, Mie University School of Medicine, Tsu, Mie, Japan
Hajime Sakuma, MD, PhD: Department of Radiology, Mie University School of Medicine, Tsu, Mie, Japan

Journal volume & issue: Vol. 17, no. 10
pp. 3867 – 3870

Abstract

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ALK-positive histiocytosis is an emerging histiocytic entity that can involve a single organ or multiple organs. This disease frequently involves the central nervous system, and the importance of immunohistochemical and genetic analyses is emphasized for the accurate diagnosis of this rare entity. However, radiological findings of this disease have not been sufficiently described. Here, we report a case of a 3-year-old boy with ALK-positive histiocytosis with systemic masses that was identified to harbor KIF5B-ALK gene fusion.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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Abstract

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