Effects of N-hydroxy-4-({[(E)-2-phenylethenyl] solfonyl}amino)butanamide on cell cycle and adhesive properties in tumor cells

Abstract

Using the model system of tumor spheroidal growth, we explored the main changes of the cell cycle parameters, adhesion properties and morphological features caused by action of a new chemically synthesized derivative of hydroxamic acid N-hydroxy-4-({[(e)-2phenylethenyl] sulfonyl}amino)butanamide, a reversible inhibitor of matrix metalloproteinases. The results of our studies, indicates that it is a possible epithelialmesenchymal transition due to increased adhesive properties, inhibition of spheroid formation and changes in cells propotion in specific phases of the cell cycle

Keywords

• N–hydroxy-4–({[(e)-2-feniletenyl] sulfonyl} amino) butanamid, reversible inhibitors of matrix metalloproteinases, epithelialmesenchymal transition, model system of spheroidal growth