Annals of Clinical and Translational Neurology (Oct 2023)

Association between brain health outcomes and metabolic risk factors in persons with diabetes

  • Evan L. Reynolds,
  • Kristen Votruba,
  • Clifford R. Jack,
  • Richard Beare,
  • Robert I. Reid,
  • Gregory M. Preboske,
  • Camille Waseta,
  • Rodica Pop‐Busui,
  • Robert G. Nelson,
  • Brian C. Callaghan,
  • Eva L. Feldman

DOI
https://doi.org/10.1002/acn3.51859
Journal volume & issue
Vol. 10, no. 10
pp. 1891 – 1898

Abstract

Read online

Abstract We performed a cross‐sectional study to determine associations between cognition and MRI‐derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1] years). Participants had similar cognition (NIH Toolbox Cognition Battery composite: 45.3 [9.8], p = 0.64, n = 51) compared to normative data. T2d duration, but not other metabolic risk factors, associated with decreased cortical thickness (Point Estimate (PE): −0.0061, 95%CI: −0.0113, −0.0009, n = 45), gray matter volume (PE: −830.39, 95%CI: −1503.14, −157.64, n = 45), and increased white matter hyperintensity volume (PE: 0.0389, 95%CI: 0.0049, 0.0729, n = 45).